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Unique Regions in the C227-11 Genome The C227-11 genome contains 58 regions longer than 100 bp that are missing in at least 1 of the other 11 prototype enteroaggregative E. Coli genomes (Table 6 in the ). These 58 regions contain 180,088 bp (about 3.4% of the genome), but more than 120,000 bp of this unique DNA comprise the two lambdalike phages mentioned above (61,022 and 59,914 bp, respectively). Most of the remaining sequence (about 60,000 bp) is made up of genes of unknown function that are also found in commensal E. Coli and thus probably do not contribute to virulence.
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The O104:H4 isolates are shown in orange, the reference enteroaggregative E. Coli (EAEC) isolates in blue, and the enterohemorrhagic E. Coli isolates in green. (The classification of the other strains is shown in Fig. 4 and Table 4 in the.) The O104:H4 isolates cluster into a single clade (dark gray); in contrast, the reference EAEC isolates are extremely divergent and are represented throughout the phylogeny., and Fig.
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